Department of Microbiology 
Department of Cancer Immunology and Virology 
PhD Program in Virology 
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  Cryo-EM structure of the mouse mammary tumor virus intasome, which is composed of eight integrase (IN) molecules and two viral DNA ends (black). Highlighted with the DNA are IN domains (NTD, N-terminal domain; CCD, catalytic core domain; CTD, C-terminal domain) that comprise the conserved intasome core structure that is observed throughout Retroviridae. The green and blue CCDs catalyze DNA recombination, whereas the cyan CCDs as well as deemphasized IN elements (grey) provide architectural support. Positionally conserved CTDs (yellow) are donated from flanking IN dimers. Modified from Ballandras-Colas A et al., 2016 Nature.